The George Parks Highway and the Glenn Highway connect the city of Wasilla to Palmer, Anchorage, Fairbanks, and Canada. While the borough is larger than West Virginia, approximately 90 percent of the residents live along the 55-mile stretch of the road system between Willow on the Parks Highway and Sutton on the Glenn Highway.

Alaska Railroad Corporation, a full-service railroad, runs passenger and freight service between Anchorage and Fairbanks. Projects are currently underway to reduce the travel time between Wasilla and Anchorage from 90 to 58 minutes. A Commuter Rail Study and Operations Plan is underway to create a profile of Wasilla residents and other Alaskans who would use a commuter rail service. Some of the essential issues to be addressed include questions about location of depots and park and rides, transport of commuters from the train depot to the workplace, ticket prices, and facilities and equipment upgrades.

Floatplanes land at Wasilla Lake, Jacobsen Lake, and Lake Lucille. In addition, 10 private airstrips can be found in the vicinity. Anchorage International Airport with commercial jet service is a little over an hour away.

Valley Transit (formally Mat-Su Community Transit) is a non-profit corporation, that has been in operation since March 1999 and provides opportunities for trips to destinations around Wasilla, and to other communities such as Palmer and Anchorage. Valley Transit provides a variety of transportation options such as a Fixed Route System for point to point service, a Demand Response System to lower density population areas such as Big Lake or Houston, and Door to Door Paratransit for seniors and disabled persons.

Wasilla Airport was constructed in 1993 on 370 acres owned by the City. The paved 3,700-foot runway for general aviation aircraft which is about 15 minutes from the heart of town replaced a previous smaller gravel airstrip located in the center of town. The Wasilla Airport includes a radio controlled runway, taxiways, security lighting, engine and airframe repair and fuel service available on site, and Air-Taxi Services. Lease lots are available and paved lease spaces for aircraft tie-down are also available. Monthly: $36.05. Semi-annually: $216.30. Annually: $432.60. The Airport is maintained to be open year round.